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Fort Lauderdale, Florida, United States. Kidney and liver failure due to alcohol abuse, was in a medically induced coma awaiting liver transplant. Singer, musician and actor. Charles Kennedy. 1 June 2015. (2015-06-01) (aged 55) Fort William, Scotland. Major haemorrhage linked to alcoholism.
Physiology of alcohol tolerance. Alcohol dehydrogenase is a dimeric zinc metalloenzyme that catalyzes the reversible oxidation of alcohols to aldehydes. Direct alcohol tolerance is largely dependent on body size. Large-bodied people will require more alcohol to reach insobriety than lightly built people. [4] Thus, men, being larger than women ...
Alcohol is the leading cause of direct deaths from drug overdoses. Symptoms of ethanol overdose may include nausea, vomiting, CNS depression, coma, acute respiratory failure, or death. Levels of even less than 0.1% can cause intoxication, with unconsciousness often occurring at 0.3–0.4%. [275]
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Chronic alcohol use is also associated with malnutrition, Wernicke-Korsakoff syndrome, alcoholic cardiomyopathy, hypertension, stroke, arrhythmias, pancreatitis, depression, and dementia. Alcohol is also an established carcinogen with chronic use associated with increased risk of cancer. [15] [16]
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