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  2. Genetically modified mouse - Wikipedia

    en.wikipedia.org/wiki/Genetically_modified_mouse

    A genetically modified mouse or genetically engineered mouse model ( GEMM) [1] is a mouse ( Mus musculus) that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research or as animal models of human diseases and are also used for research on genes.

  3. Humanized mouse - Wikipedia

    en.wikipedia.org/wiki/Humanized_mouse

    A humanized mouse or a humanized mouse model is one that has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be utilized for gaining relevant insights in the in vivo context for understanding of human-specific physiology and pathologies. [3] A lot of knowledge about several human biological ...

  4. Patient derived xenograft - Wikipedia

    en.wikipedia.org/wiki/Patient_derived_xenograft

    Patient derived xenograft. Patient derived xenografts ( PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse. [1] It is a form of xenotransplantation. PDX models are used to create an environment that allows for the continued growth of cancer after its removal from a ...

  5. BALB/c - Wikipedia

    en.wikipedia.org/wiki/BALB/c

    BALB/c. BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation. [ 1]

  6. Nude mouse - Wikipedia

    en.wikipedia.org/wiki/Nude_mouse

    Nude mouse. A nude mouse. A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname.

  7. C57BL/6 - Wikipedia

    en.wikipedia.org/wiki/C57BL/6

    It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...

  8. Knockout mouse - Wikipedia

    en.wikipedia.org/wiki/Knockout_mouse

    Knockout mouse. A knockout mouse, or knock-out mouse, is a genetically modified mouse ( Mus musculus) in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are important animal models for studying the role of genes which have been sequenced but whose ...

  9. Laboratory mouse - Wikipedia

    en.wikipedia.org/wiki/Laboratory_mouse

    The albino laboratory mouse is an iconic model organism for scientific research in a variety of fields. An SCID. Intermediate coat colour. Kept as a pet. The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets. Laboratory mice are usually of the species ...

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